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Paula's Choice Clinical 1% Retinol Treatment scores 8.9/9.8 vs Vichy Liftactiv Serum 10 Supreme at 6.8/9.8. Paula's Choice Clinical 1% Retinol Treatment wins for active ingredients.
Paula's Choice Clinical 1% Retinol Treatment takes this one, winning 3 of 5 attributes.
Scores last verified: April 2026
38 unique
9 in common
19 unique
Where Paula's Choice Clinical 1% Retinol Treatment really shines is active ingredient strength, scoring 7.1 compared to Vichy Liftactiv Serum 10 Supreme's 2.5. Its formula features Retinol, Palmitoyl Tetrapeptide-7, and Dipotassium Glycyrrhizate in high positions, signalling meaningful concentrations.
Hydration Efficacy is another area of separation. Paula's Choice Clinical 1% Retinol Treatment scores 9.8 here versus 6.8 for Vichy Liftactiv Serum 10 Supreme. That difference comes down to how each formula is built — the ingredient list tells the story.
Paula's Choice Clinical 1% Retinol Treatment brings Retinol, Palmitoyl Tetrapeptide-7, and Dipotassium Glycyrrhizate as actives, while vichy Liftactiv Serum 10 Supreme relies on Adenosine and Tocopherol. Both approaches have merit, but the positioning and supporting ingredients make the difference.
Paula's Choice Clinical 1% Retinol Treatment is better if you have
Vichy Liftactiv Serum 10 Supreme is better if you have
Paula's Choice Clinical 1% Retinol Treatment comes in at mid-range pricing with a 8.9 score, which is solid value at that tier.
Paula's Choice Clinical 1% Retinol Treatment wins this comparison with a meaningfully stronger ingredient profile and overall score.
Based on ingredient analysis, Paula's Choice Clinical 1% Retinol Treatment scores higher overall. See the full score breakdown above for details on each attribute.
Yes, they share common ingredients. Check the ingredient face-off section above for a detailed comparison.
The key differences are in their active ingredients and formulation approach. Check the attribute battle above for a detailed breakdown.
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