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Paula's Choice Clinical 1% Retinol Treatment scores 8.9/9.8 vs Klairs Fundamental Ampule Mist at 7.3/9.8. Paula's Choice Clinical 1% Retinol Treatment wins for active ingredients.
Paula's Choice Clinical 1% Retinol Treatment takes this one, winning 3 of 5 attributes.
Scores last verified: April 2026
7 unique
42 unique
Where Paula's Choice Clinical 1% Retinol Treatment really shines is active ingredient strength, scoring 7.1 compared to Klairs Fundamental Ampule Mist's 2.6. Its formula features Retinol, Palmitoyl Tetrapeptide-7, and Dipotassium Glycyrrhizate in high positions, signalling meaningful concentrations.
Hydration Efficacy is another area of separation. Paula's Choice Clinical 1% Retinol Treatment scores 9.8 here versus 7.2 for Klairs Fundamental Ampule Mist. That difference comes down to how each formula is built — the ingredient list tells the story.
Paula's Choice Clinical 1% Retinol Treatment brings Retinol, Palmitoyl Tetrapeptide-7, and Dipotassium Glycyrrhizate as actives, while klairs Fundamental Ampule Mist relies on Centella Asiatica Extract, Allantoin, and Arginine. Both approaches have merit, but the positioning and supporting ingredients make the difference.
Klairs Fundamental Ampule Mist is better if you have
Paula's Choice Clinical 1% Retinol Treatment is better if you have
Both sit in the mid-range bracket, so value comes down to formulation quality. Paula's Choice Clinical 1% Retinol Treatment gets the nod here with its 8.9 overall score — you're getting more for a similar outlay.
Paula's Choice Clinical 1% Retinol Treatment wins this comparison with a meaningfully stronger ingredient profile and overall score.
Based on ingredient analysis, Paula's Choice Clinical 1% Retinol Treatment scores higher overall. See the full score breakdown above for details on each attribute.
Yes, they share common ingredients. Check the ingredient face-off section above for a detailed comparison.
The key differences are in their active ingredients and formulation approach. Check the attribute battle above for a detailed breakdown.
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