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Paula's Choice Clinical 1% Retinol Treatment scores 8.9/9.8 vs Anua Heartleaf 80% Soothing Ampoule at 7.8/9.8. Paula's Choice Clinical 1% Retinol Treatment wins for active ingredients.
Paula's Choice Clinical 1% Retinol Treatment takes this one, winning 3 of 5 attributes.
Scores last verified: April 2026
10 unique
8 in common
39 unique
Where Paula's Choice Clinical 1% Retinol Treatment really shines is active ingredient strength, scoring 7.1 compared to Anua Heartleaf 80% Soothing Ampoule's 4.7. Its formula features Retinol, Palmitoyl Tetrapeptide-7, and Dipotassium Glycyrrhizate in high positions, signalling meaningful concentrations.
Hydration Efficacy is another area of separation. Paula's Choice Clinical 1% Retinol Treatment scores 9.8 here versus 7.9 for Anua Heartleaf 80% Soothing Ampoule. That difference comes down to how each formula is built — the ingredient list tells the story.
Paula's Choice Clinical 1% Retinol Treatment brings Retinol, Palmitoyl Tetrapeptide-7, and Dipotassium Glycyrrhizate as actives, while anua Heartleaf 80% Soothing Ampoule relies on Niacinamide, Allantoin, and Dipotassium Glycyrrhizate. Both approaches have merit, but the positioning and supporting ingredients make the difference.
Anua Heartleaf 80% Soothing Ampoule is better if you have
Paula's Choice Clinical 1% Retinol Treatment is better if you have
Both sit in the mid-range bracket, so value comes down to formulation quality. Paula's Choice Clinical 1% Retinol Treatment gets the nod here with its 8.9 overall score — you're getting more for a similar outlay.
Paula's Choice Clinical 1% Retinol Treatment wins this comparison with a meaningfully stronger ingredient profile and overall score.
Based on ingredient analysis, Paula's Choice Clinical 1% Retinol Treatment scores higher overall. See the full score breakdown above for details on each attribute.
Yes, they share common ingredients. Check the ingredient face-off section above for a detailed comparison.
The key differences are in their active ingredients and formulation approach. Check the attribute battle above for a detailed breakdown.
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