8.1
Paula's Choice
Clinical Niacinamide 20% Treatment
serummid-range
Overall score8.1
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Paula's Choice Clinical Niacinamide 20% Treatment scores 8.1/9.8 overall. It ranks highest in low irritation risk (9.5) and formulation safety (9.0).
Vitamin B3 that brightens and strengthens skin barrier
Humectant with antimicrobial properties
Lightweight humectant and solvent
Estimated — based on ingredient analysis. Scores refine as user reviews are added.
Scores last verified: April 2026
Paula's Choice Clinical Niacinamide 20% Treatment is an excellent serum with an overall score of 8.1/9.8. Positioned in the mid-range bracket, it delivers a well-rounded formulation that balances efficacy with gentleness. The formula leads with Niacinamide, Pentylene Glycol, Butylene Glycol — ingredients that actively target skin concerns.
It performs well on hydration (6.8) and low irritation risk (9.5) and active strength (6.7).
Great for
Works on your skin — #2 in the INCI list
Draws in moisture — #3 in the INCI list
Draws in moisture — #4 in the INCI list
23 ingredients — listed in INCI order (highest concentration first)
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© 2026 Gracie. All rights reserved. Data sourced from Open Beauty Facts (ODbL) and EU CosIng.
Draws in moisture — #5 in the INCI list
Works on your skin — #6 in the INCI list